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Missing data methodology for multi-level models

Researchers

Professor Michael G Kenward, Dr James Carpenter, London School of Hygine and Tropical Medicine

Professor H. Goldstein, Institute of Education

Professor G. Molenberghs, Limburgs University


December 2002 - December 2004

A Methods Briefing provides summary results from this project

 

Context

  • Missing data is ubiquitous in social science research, especially if data are longitudinal;
  • This causes uncertainty in scientific inference, that goes beyond familiar sampling variation;
  • When data are missing, the sensitivity of conclusions to assumptions about the missing data should be examined.

Aims and Objectives

  • Explore how analyses with missing data can be formalised and used by social scientists using multi-level modelling;
  • Compare and where necessary substantially develop the most appropriate methods;
  • Provide software for use by social scientists;
  • Provide a web site for dissemination, discussion and training;
  • Organise workshops.

Methodological aspects

  • The reasons for missing data are the key to choosing an appropriate analysis. However, these are invariably unknown;
  • Therefore, methodology which transparently conveys the sensitivity of analysis to the assumptions about the missing data is required;
  • There is a particular need for this in multi-level models which are widely used in social science.

Sensitivity of treatment estimate (blue plain) to effect of rescue medication.
95% confidence plains in red. Null plain in black.

Research Design

  • Review the three broad classes of approach to missing data emerging in the recent literature;
  • Understand how they relate to each other;
  • Develop them to address research questions arising from Belgian Health Interview Survey and Institute of Education's class size project;
  • Foster accessible discussion of recent methodological developments using forthcoming web site;
  • Promote good practice by making example analyses available on the web.

Outputs

  • Coming soon: www.missingdata.org.uk , containing teaching, discussion and research;
  • Articles, software and reviews posted on web site;
  • Four workshops in 2004.

Contact Name: Professor Michael Kenward
Email: mike.kenward@lshtm.ac.uk
Phone: 020 7927 2472
Website: www.lshtm.ac.uk/msu/missingdata/